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[DOI] [PubMed] [Google Scholar] 25.Hosoki R., Matsuki N., Kimura H

49,50 G6PD or PGD depletion significantly decrease NADPH levels and enhance chemotherapeutic drugs-induced cell apoptosis by redox modulation

Mechanistically, PKM2 lactylation alters its conformation to a preferential tetrameric over its otherwise dimeric/monomeric form, and thereby reduces PKM2 nuclear accumulation, where it would otherwise drive the expression of proglycolytic genes in interaction with HIF1 (Wang et al., 2022) as well as pro-inflammatory genes (Shirai et al., 2016)

4) supports the hypothesis of a feedback inhibition

The only differences are the indication on the label and the packaging