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Macrophages can also express mechanosensitive ion channels to modulate cellular activity through the gating of soluble ions

H 2 S is implicated in the pathogenesis and therapeutic interventions of chronic obstructive pulmonary disease, as endogenous H 2 S is involved in the regulation of physiological functions of the respiratory system and pathophysiological alterations, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and hypoxia-induced pulmonary hypertension [105]