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Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

This systematic review ultimately included 19 studies, consisting of 14 RCTs, 2 usability studies, and 3 experimental studies (Figure 1, Table 1, Supplementary Table 1) (Haddaway et al., 2022)

However, DAO levels are affected by factors such as diet [86], alcohol consumption [87], sex [88], menstrual cycle [89] and pregnancy status [90] which challenge its reliability as a biomarker [91]