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The goal for this cohort is to observe how MTX325 modulates PD biomarkers, although its unclear what specific biomarkers Mission is pursuing

Within minutes of administration, changes occur in Akt1, VEGFR2, and eNOS expression

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Examples: manual muscle testing grades by major muscle groups transfer ability (sit-to-stand, bed-to-chair) gait observations and balance findings functional test results (timed sit-to-stand, walking tolerance, assistive device use) Step 3: Prove functional impact Link weakness to daily life: bathing, dressing, toileting meal prep, household mobility fall risk and safety concerns work limitations when relevant Step 4: Exclude focal and neurologic patterns Document why this is generalized rather than focal: no unilateral deficit pattern no dermatomal-only weakness pattern

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