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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

The exact pathogenesis of ferroptosis has not yet been clarified

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found that mice fed diets lacking serine and glycine showed a reduction in tumor sizes and survived longer than those fed diets containing the amino acids, indicating that diet regulation may be a potential therapy for investigation [142]