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m - o , Levels of various nutrients in the administered diet (yellow) and in Het (blue) or KO (red) stool from microbiota-depleted mice fed on a No Cys diet for 3 days

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Critical depletion of GSH in mitochondria culminates in increased levels of ROS and RNS, mitochondrial dysfunction and subsequent ATP depletion, which are responsible for the shift from apoptosis towards necrosis and, therefore, inflammation