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This study showed that inhibiting HMGB1 nucleocytoplasmic translocation pharmacologically and deleting HMGB1 in TECs in mice were effective in preventing IRI-AKI, tubular ferroptosis, and inflammation compared to control groups [48]

644 Beyond the well-known mechanisms of central sensitization and peripheral nerve injury, NeP is also characterized by oxidative stress, excessive iron accumulation, and lipid peroxidation damage

The oxidative stress in the CNS is associated to many neurodegenerative diseases

Quantification of Sirius Red staining in livers from Glul (+/+)Hep and Glul (/)Hep mice ( n = 3 per group)

Although conceptually distinct, in practice, many biomarkers used in trials perform both roles simultaneously