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For some people, the answer is yes, though it is usually temporary and often related to the specific form of the supplement

Traditionally, people and animals got B12 from eating food from the ground and drinking non-treated water but with so many farmed animals now confined in factory farms, they are fed B12 supplements

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action

So if its been identified via a blood test (through a health professional) and your doctor recommends injections, it is important to get those B12 levels up

161 Viral hepatitis Studies have shown that HBV C protein (HBc) and HBV E protein (HBe) caused lower cfDNA levels in patients with chronic hepatitis B infection