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Quantitatively, haemoglobin and haemoglobin-haptoglobin complexes are likely to be the most significant extracellular sources of haem in vivo (Seale et al., 2006)

It is an extremely complicated process where a lot of internal and external factors are involved in both steps (Drubin et al., 1985

10.1021/bi050840w 55 JayasingheS

(7) Sarah Wrigley, Donia Arafa, and Daniela Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiets in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14