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Although high extracellular calcium is known to inhibit hemichannel opening [41,42], several studies have reported that an increase in intracellular calcium can positively regulate connexin hemichannel activity [43,44]

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Introduction Obesity is a chronic complex disease contributing to the development of various obesity-related comorbidities, such as metabolic syndrome and dysfunction, type 2 diabetes, cardiovascular diseases, depression, and certain cancer forms [1]

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