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There were no significant differences between older and younger subgroups with regard to developing responsiveness based on AIMS or CGI-TD scales

Antibody production by follicular B cells is T cell-dependent, whereas B1 and marginal zone B cells rapidly respond to blood-borne antigens in a T cell-independent manner [93]

Ishikawa K, Weber T, Hajjar RJ

Hersh et al., 2022)

Mitochondrial dysfunction is one of the hallmarks of aging, and its interaction with oxidative stress and inflammation also contributes to the regulation of aging, given that oxidative stress and inflammation are also triggers of aging