intracellular glutathione pools are heterogeneously concentrated

intracellular glutathione pools are heterogeneously concentrated SLC33A1 exports oxidized to maintain endoplasmic reticulum redox homeostasis Glutathione (GSH), a powerful intracellular

Name: intracellular glutathione pools are heterogeneously concentrated SLC33A1 exports oxidized to maintain endoplasmic reticulum redox homeostasis Glutathione (GSH), a powerful intracellular
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Glutathione (GSH), a powerful intracellular antioxidant, plays a Download Scientific Diagram Frontiers Iron tracking strategies: Chaperones capture iron in the cytosolic labile iron pool Glutathione Related Enzymes and Proteins: A Review Frontiers Ferroptosis: Mechanism and connections with cutaneous diseases Real time imaging of the intracellular glutathione redox potential Nature Methods

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Additionally, in the KEYNOTE-859 phase III trial assessing patients with locally advanced or metastatic HER2-negative gastric or gastro-oesophageal junction adenocarcinoma, adding pembrolizumab to platinum/chemotherapy treatment significantly improved OS with a manageable toxicity profile compared to the placebo/chemotherapy group [111]

Secondly, it may activate short-chain fatty acid receptors (SCFA receptors) and inhibit histone deacetylase (HDAC) activity, thereby lifting transcriptional repression on key iron absorption genes (such as Dcytb and Ferroportin) and consequently upregulating intestinal iron uptake