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Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management

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10.1186/1471-2474-12-86 21 JohannsenF.OlesenJ

Activated mTOR inhibits autophagy by suppressing the phosphorylation of the Unc-51-like kinase 1 (ULK1)Atg13Atg101focal adhesion kinase family interacting protein of 200 kDa (FIP200) complex [96,97,98]

This intrinsic mechanistic complexity is further compounded by the substantial inter-individual variability in gut microbiota composition, BA profiles, host genetics, and immune responsiveness (166)