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Nicotine present in cigarettes relaxes the lower esophageal sphincter (LES), thereby allowing acid to escape into the esophagus

Here, the researchers undertake a systematic review (a study that uses predefined criteria to identify all the research on a given topic) and a meta-analysis (a statistical approach for combining the results of several studies) to investigate this issue

Onset could be infancy, childhood, middle age or later

By triggering the brains reward centers and suppressing its judgment systems, they make harmful behaviors feel good in the short term, despite their long-term risks