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Biochemistry 2000

The microbiome as a modifier of neurodegenerative disease risk

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Activity of the NLRP3 inflammasome has been shown to be directly inhibited by BHB via decreased K + efflux and reduced ASC speck formation, leading to decreased production of IL-1 and IL-18 in human monocytes and in vivo models (98)

Of enzymes that converts epoxyeicosatrienoic acids (EETs) to DHETs, the levels of microsomal epoxide hydrolase (EPHX1) positively correlated with fibrosis stage, but not soluble epoxide hydrolase (EPHX2)