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The biggest one is stacked GI side effects - nausea, vomiting, diarrhea, and constipation - because both compounds slow digestion

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it appears to recapitulate the intracellular signals that exercise generates, including AMPK activation, mitochondrial biogenesis, and GLUT4 upregulation, in tissues that can no longer experience them through movement

doi: 10.1016/j.trac.2023.117066 Higgins L, Gerdes H, Cutillas PR

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