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Glycerol hardly varies in R cells (strongly decreased in S cells), whereas m- inositol increases more clearly in R cells) (Additional file 4)

It is also essential to integrate biological markers (e.g., BDNF, IGF-1, VEGF, inflammatory cytokines) and neuroimaging measures (e.g., functional connectivity, hippocampal volume) into future studies, to better understand underlying mechanisms and personalize interventions

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This can help numb the area, reduce swelling, and alleviate pain

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