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20% of NB patients and drives half of the aggressive forms of the disease with poor outcomes ( MYCN transcriptional machinery, synthetic lethality, and destabilization of the MYCN protein (6, 7)

Historical Background and Scientific Context Mitochondrial-derived peptides emerged as an important area of scientific research following the discovery that mitochondrial DNA encodes biologically active peptides capable of participating in intracellular signalling networks

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Research by Heffernan et al

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