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this phenomenon causes mitochondrial dysfunction with increased superoxide radical levels at peak pain, triggering signaling cascades that may underlie the coasting effect, such as apoptosis

Overdosage of benzodiazepines in combination with other CNS depressants (including alcohol and opioids) may be fatal [see Warnings and Precautions (5.2)]

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Human Uterine Smooth Muscle and Leiomyoma Cells Differ in Their Rapid 17beta-Estradiol Signaling: Implications for Proliferation