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Stimulation of the receptors upon binding of its ligands, for example with interalia AGE, leads to the activation of several molecular signalling pathways, including the PI3K/AKT, JAK/STAT, NF-B, Ras/MAPK, Rac1/cdc42, p44/p42, p38 and SAP/JNK/MAPK pathways, which contribute to the expression of transcription factors, such as NF-B, STAT3, HIF-1, AP-1 and CREB

However, we did not study circadian-related markers such as CLOCK, BMAL1, CRY, and PER1/2

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Anti-Aging & Longevity Studies Research reveals activation of sirtuin 1 pathways through preserved NAD+ levels, triggering longevity-associated genetic programs including enhanced DNA repair, improved mitochondrial function, and reduced inflammatory responses