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This overexpression led to significant changes in muscle fiber composition, promoting oxidative fibers and enhancing enzymatic activities and genes involved in oxidative metabolism

Selected mouse studies did not find a significant reduction in food intake

While this protein was an interesting target warranting further investigation, given the smaller sample size and duration post sample collection, we sought to determine if these findings were replicable in a larger and more recent study cohort

This means that when looking for toxicants in human brains, large numbers of participants are required, since the relevant toxicant may only be observable if the toxicant exposure was recent or ongoing