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GSTO1 knockdown as well as the small-molecule GSTO1 inhibitor C1-27 also caused downregulation of the Wnt inhibitor Dickkopf 1 ( DKK1 ), thombospondin 1 ( THBS1 ), the cysteine-rich angiogenic inducer CYR61 and caveolae scaffolding proteins CAV1 and CAV2 , among others

The confidence is remarkable given the near-total absence of clinical evidence behind most of it

PubMed searches return zero combined trials as of early 2026

Nanomedicine 48, 102649

cerevisiae KACC 48331, originally isolated from Makgeolli brewed in Yeongam, Korea, was selected as the glutathione-producing strain for its superior glutathione yield and development potential