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The route and dosage of supplementation depend on the severity of deficiency, presence of neurological symptoms, and underlying cause of the deficiency

Reports also describe shrinkage of adipocyte size and reductions in fat-pad mass while preserving insulin signaling markers in certain models

2019 (Lancet HIV, n=61) Phase II investigator-initiated trial in HIV-NAFLD: about 32% liver-fat reduction and lower fibrosis-progression rate versus placebo at 12 months

Wrinkle depth may reduce measurably during this phase

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