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The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins

Then, the mixture was purified directly by reverse phase chromatography on a C18 column (H 2 O/acetonitrile [CH 3 CN] from 9/1 to 0/10 with 0.1% of TFA) delivered the corresponding Mito 10 -NAC (0.15 g, 83% yield)