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Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]

[DOI] [PubMed] [Google Scholar] 173.Misra S, Chaturvedi A, Misra NC, Sharma ID

Metabolomics evolved as sensitive tool to detect these alterations by profiling shifts in amino acids, organic acids, fatty acids and osmolytes that serve as biomarkers of stress exposure