chac1 glutathione CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers BACH1–CHAC1–Glutathione Axis Aggravates Myocardial Ischemia–Reperfusion
BACH1CHAC1Glutathione Axis Aggravates Myocardial IschemiaReperfusion Injury by Enhancing Ferroptosis and Oxidative Stress Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Calcium channel mutants rescue the effect of glutathione depletion. (A) Download Scientific Diagram Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect
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