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Subsequently, iron is released from transferrin and undergoes reduction to its divalent form by lysosomal reductases before being transported into the cytosol via divalent metal transporter 1 (DMT1) and transient receptor potential mucolipin (TRPML1/2), ultimately entering the cellular labile iron pool (LIP) [97]

doi: 10.3390/ijms20246318 73 ShenR

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Blocking IL-23 results in a downstream block of IL-22 and pathogenic Th17 cells involved in bone loss pathogenesis