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Reconstitution Guidelines: Reconstitute with sterile bacteriostatic water or a suitable buffer according to your experimental requirements

The data demonstrate the inhibitory effect of Epitalon in the development of spontaneous mammary tumors in HER2/neu mice, suggesting that a downregulation of HER2/neu gene expression in mammary adenocarcinoma may be responsible, at least in part, for the antitumor effect of the peptide

Any use should be discussed with a healthcare provider

Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)