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*The compound is unstable in solutions, freshly prepared is recommended Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide

Isotretinoin metabolites, particularly 4-oxo-isotretinoin, also raise hepatic ROS and deplete glutathione stores [8]

Low temperatures slow it dramatically

doi:10.1016/j.actbio.2017.08.041

Heat Shock Proteins HSPA1 and HSP90AA1 Are Upregulated in Colorectal Polyps and Can Be Targeted in Cancer Cells by Anti-Inflammatory Oxicams with Arylpiperazine Pharmacophore and Benzoyl Moiety Substitutions at Thiazine Ring