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A PDX biobank specifically focused on BRAF V600E -mutated gliomas is currently lacking due to the scarcity of patient material, and the difficulty in retrieving complete patients clinical data, pathologies, gene expression profiles, and drug responsiveness ( 3.3 Syngeneic murine models These models are created by implanting an established tumor cell line derived from the same species as the host animal

To this end, cDNA sequences encoding the first 21, 30, 42, and 60 amino acids of GSH1 were translationally fused to a CrVenus reporter (Mackinder et al., 2016) and expression of the the GSH1 reporters (GSH1 n21 : Venus, GSH1 n30 :Venus, and GSH1 n42 :Venus) were verified by immunoblotting (Supplemental Figure S5A)

, Zhang, G

Another added value of this work was the study of erythrocytes as a simplified model of human metabolism

RAW cells showed increased extracellular ROS formation when treated with 33 M acrolein (Fig