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Lapelusa, M, San Lucas, FA, Iorgulescu, B, Patel, KP, You, YN, Foo, WC, Maru, DM, Kopetz, S , Ludford, K, Morris, VK, Overman, MJ

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This modification strengthens the interaction of PIK3C3/VPS34 with BECN1, ATG14, and UVRAG, enhances its lipid kinase activity, and promotes both macroautophagy and endolysosomal degradation