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IGF-1 over-expressing mice showed hypermyelinated axons (Ye et al., 1995), whereas IGF-1 knockout mice exhibited a decreased number of oligodendrocytes and hypomyelination (Beck et al., 2002)

N Engl J Med 334(22):14481460 Topal G, Brunet A, Millanvoye E, Boucher J, Rendu F, Devynck M, David-Dufilho M (2004) Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin

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Normal ovarian function and ovulatory regulation in PCOS depend on the enhancement of insulin action and glucose homeostasis through molecular modulation of these agents

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