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Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes Diana Trofimovitch 1 , Steven J Baumrucker 2 Curr Pain Headache Rep 2020 Aug 26;24(10):64

Vomiting rates with cagrilintide monotherapy were significantly lower than with GLP-1 receptor agonists

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The proposed mechanism involves maintaining synaptic vesicle integrity, competing for receptor sites, and potentially substituting for depleted neurotransmitters

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