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In the case of isolated locoregional lymph node (LN) metastases, surgical removal of the tumor-bearing LN alone is insufficient

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These include: Oxidative stress: One of the more recent studies on DSIP, from 2011, concluded that the peptide has a strong antioxidant effect owing to an ability to activate the (rat) bodys natural mechanisms against oxidative stress.21 Edema (swelling via fluid buildup): Again in rats, a 1992 study suggested that DSIP may have an antiedematic effect related to the activation of the GABAergic system and inhibition of serotonin, noradrenaline, and histamine systems.22 Convulsions: Two rodent studies in the 1990s support DSIPs use as an anticonvulsant

Based on the mechanism of action of ganaxolone and work in preclinical animal models suggesting improved spatial memory function in an animal model of Angelman Syndrome (393), future investigation looking at the clinical value of this agent in anxiety disorders appears warranted

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