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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

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A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats

Overall, these results suggest that although PEP availability could be a limiting factor for the in vivo glucose-PTS activity, L

examined the effects of Oleanolic acid (OA) preconditioning in a rat model of I/R injury (104)