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If your MTHFR gene mutation reduces folate metabolism, the risk of pregnancy complications rises significantly, including neural tube defects (spina bifida, cleft lip/palate), Down syndrome, preeclampsia, recurrent losses and more

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It might be associated with mental retardation, rheumatoid arthritis or obstructive lung disease 12

By integrating biochemical, nutritional, and metabolic analyses, a comprehensive assessment of the methionine cycle can reveal insights into its role in methylation homeostasis, disease susceptibility, and metabolic adaptation to environmental and physiological stressors