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However, various physicochemical and biological factors within the IVD microenvironment, such as pH, osmotic pressure, hypoxia, inflammation, and mechanical stress, severely compromise the survival and function of transplanted cells

Subsequently, divalent metal transporter 1 (DMT1) transports Fe + into the cytoplasm ( + ) can participate in the Fenton reaction, generating hydroxyl radicals (OH), which initiate and propagate lipid peroxidation chain reactions, thereby acting as one of the key triggers of ferroptosis ( + in ferritin, a cytosolic iron storage protein