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Under different conditions, any option can be the first line of treatment

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

Chronic stress and the resulting hyperactivity of the HPA axis have been shown to lead to a decrease in serotonin levels in the brain, particularly in regions such as the prefrontal cortex (PFC) and hippocampus, which are essential for mood regulation

While the precise mechanisms linking these metabolic alterations to fibrotic remodeling remain to be fully elucidated, current studies strongly support amino acid metabolism as a central regulatory axis in fibrosis initiation and progression

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