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By permitting capture of evidence for a state with flavin spectral perturbation and long-wavelength charge transfer prior to NADPH oxidation and flavin reduction, the Y296A variant confirms what was proposed for the C159S above (Figure 3A)

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Thus far, APAP is the most common drug used to establish DILI mice models, given evidence demonstrating a shared mechanism of APAP toxicity between humans and mice [82]

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This facilitates the enhanced entry of aminoglycosides into the cell, allowing greater access to their ribosomal targets