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As we age, our bodys ability to create those chemicals naturally declines, so we give it a boost with Hormone Replacement Therapy

The main interaction caution is with anticoagulant medications (as mentioned, due to bleeding risk) not typically relevant to young ADHD patients, but possibly to adults who might be on other meds

*Correspondence: Su-Mei He, [email protected] Zhu, [email protected] Wei, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Clinical Nutrition, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Using saccharin as a prototype sweetener at a dose corresponding to the ADI for humans (5 mg/kg per day), the authors further characterised the faecal microbiota composition of saccharin-consuming mice and demonstrated that saccharin induced strong dysbiosis, with an increase in the number of bacteria from the Bacteroides genus and the Clostridiales order