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doi: 10.1109/TCBB.2018.2879504

These phases are shaped by the paradigm of selecting an initial hit compound from a molecular library, which is then iteratively elaborated into a lead series with improved potency, selectivity, and drug-like properties 15

GSH degradation is a key determinant of GSH homeostasis, in addition to its biosynthesis [8]

Transcripts were assembled and quantified using Stringtie 84,85 , and differential expression analysis was performed using edgeR on genes with a CPM of at least 1 in all samples 86,87