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Krppel-like factor 4 regulates macrophage polarization

References: [1]Current Patent Assignee: PROTEOSTASIS THERAPEUTICS - WO2016/105485, 2016, A2 Location in patent: Paragraph 0142

And then you also looked at mice that were genetically manipulated

The symptoms are related to heightened sympathetic activity, and central nervous system (CNS) activation and can include agitation, tremors, and sweating

However, several challenges remain, including the black box nature of AI systems (such as issues of model interpretability and liability in AI-assisted diagnosis), reliance on high-quality annotated data, limited generalizability across real-world clinical settings (including model performance stability across novel scenarios, devices, diverse populations, and disease stages), and the potential for algorithmic bias (leading to diagnostic disparities due to overrepresentation of certain demographic groups in training data)