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Sun C, Rosendahl AH, Wang XD, et al

A few commercially available colorimetric enzyme assays use substrates for recognition and dye colorants for signaling through surface adsorption/desorption

(4) 1986: George Brooks proposed the "Lactate Shuttle Theory," identifying lactate as a key energy substrate and signaling molecule between tissues

Geschwind DH: Autism: many gnes, common pathways

Since angiogenesis support the growth of cancer cells with vital factors, such as oxygen and nutrients, the inhibition of vasculature can be a pivotal strategy for cancer therapy