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Abnormal proliferation of these cells can lead to their differentiation into squamous cell carcinoma, which subsequently progresses to undifferentiated spindle cell carcinoma

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At the cellular and molecular levels, the expression of femoral OPG and RANKL proteins, fecal SCFAs and colonic FOXP3 cells, and ZO-1 and Occludin proteins were elevated, together with the upregulation of serum cytokines IL-10 and TGF- and the downregulation of IL-17 and TNF-

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Cancer Cell 13 , 5868 (2008)