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Peak concentrations, typically measured 30 min after completion of the intravenous infusion, serve as surrogates for concentration-dependent bactericidal activity, as reflected in the Cmax/MIC ratio

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D-Serine, synthesized by serine racemase in both astrocytes and neurons, serves as a co-agonist at NMDA-type glutamate receptors, playing a pivotal role in modulating synaptic plasticity and possibly influencing neuronal recovery processes, although its role in axonal regeneration remains to be fully defined [101]