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Researchers noted this when they found that ghrelin deficient mice had fewer blood vessels in their white fat tissue than other mice [8]

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Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

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Additionally, combination therapies targeting ferroptosis with conventional DN treatments (e.g., SGLT2 inhibitors and RAS blockers) are understudied