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MOTS-C is a mitochondrial-derived peptide that improves cellular insulin sensitivity and metabolic efficiency essentially making the cellular machinery more receptive to fat burning

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5-Amino-1MQ was developed as a pharmacological tool to inhibit NNMT activity, and preclinical studies have demonstrated that oral administration of 5-Amino-1MQ to obese rodents produces dose-dependent reductions in body weight and fat mass, improvements in glucose metabolism and insulin sensitivity, and increases in energy expenditure - remarkably, these effects occur without changes in food intake, indicating that 5-Amino-1MQ works through metabolic enhancement and increased caloric burn rather than appetite suppression

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1998 observed that topical copper-binding peptide cream increased procollagen production in 70% of subjects, vs