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Melatonin reverses the doxorubicin-induced upregulation of ACSL4 and downregulation of GPX4 and yes-associated protein 1 (YAP1)

Conclusion: Here we report a novel function of portal fibroblasts as drivers of cholestatic fibrosis, ductular reaction, inflammation, hepatocyte senescence, and HCC in aged mice, demonstrating the key role of the tumor microenvironment

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This enhanced structural integrity improves the skin's ability to shed damaged, hyperpigmented cells and replace them with healthy, evenly pigmented ones