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Based on the strong demand, increased glutamine catabolism may lead to glutamine deprivation and competition for glutamine, especially in the core region of solid tumors, which often display glutamine deficiency compared with other amino acids ( Here we found that THP-1 AML tumor cells but also immune cells can express and upregulate GS expression under metabolic pressure

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Finally, when evaluating the combined effect of the three factors, the treatment with 1.0 mg L 1 2,4-D in liquid medium and darkness resulted in the highest induction and proliferation of embryogenic callus ( p 0.05) (Table 3