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These observations, while not formal clinical trials for acne, highlight its potential for broader skin health benefits

J Chromatogr B Biomed Appl 661:231235 Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse

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This dual role of ubiquitination in both potentially targeting ChaC1 for degradation and stabilizing it highlights a nuanced regulatory mechanism where the context and perhaps the nature of the ubiquitin linkages or chains may dictate the ultimate fate of the ChaC1 protein